In MYP Personal Project, I studied the link between environment and the development of several mental illnesses, therefore when I was directed from Biology to World Studies, I took the opportunity to look deeper into the link between the biological and psychological development of depression and how antidepressants treat depression, however, I struggled to direct my thinking into focusing a research question with a smaller lens to study health. I was curious why there were different antidepressants and why some don’t work for different people. My supervisor suggested isolating gender, as gender is a genetic factor that may have a permanent influence on the drugs’ effect. My initial strategy is to understand biologically and psychologically who depression occurs in and why, and what antidepressants affect. I feel this is base knowledge to understanding if and why there are gender differences that can be used to better understand and treat depression across high-risk populations