While initial research over depression from a biological and psychological viewpoint has been fairly straightforward, finding research that explores different factors that affect the manifestation of depression has been extremely difficult. The research is present, however the language used is often very technical and requires more in depth biology knowledge that I currently lack, and the results of the studies are often inconclusive. This doesn’t mean that it hasn’t been successful, however it has been far harder to explore gender based differences than I initially thought. Through this challenge, I have focused more on the use of models and the experimental method in order to investigate the relationship between gender and antidepressant efficacy. I have realized the importance of a flexibility and a multi-faceted approach to researching, especially as I’ve discovered many sources that all may be applicable in some regards, but are not necessarily the best suited to the task at hand.