When Desdemona advocates on Cassio’s behalf, she initiates the first real onstage conversation she has had with her husband throughout the play. She also displays her strong, generous, and independent personality. In addition to his burgeoning suspicion, Othello’s moodiness may also result from his dislike of Desdemona herself. Given how much is at stake for Othello in his idea of Desdemona, it is remarkable how he becomes completely consumed by jealousy in such a short time. Moreover, it takes very little evidence to convince him of her unfaithfulness. All Iago has to do to Othello is make him doubt Desdemona, and jealousy spreads like a virus until he rejects her absolutely. Notably, Iago, too, has no evidence that Othello has slept with Emilia, but the suspicion or doubt seems to have been sufficient to make him spurn Emilia and persecute Othello. As Othello says, “[T]o be once in doubt / Is once to be resolved” (III.iii.183–184). Othello’s rejection of his wife’s offering of physical solace (via the handkerchief), and his termination of the exchange in which Desdemona argues for Cassio, thereby asserting a marital right, clearly demonstrate this incompatibility.
Othello’s rejection of Desdemona’s offer of her handkerchief is an emphatic rejection of Desdemona herself. He tells her he has a pain “upon” his forehead and dismisses her handkerchief as “too little” to bind his head with, implying that invisible horns are growing out of his head. Horns are the traditional symbol of the cuckold, a husband whose wife is unfaithful to him. Othello’s indirect allusion to these horns suggests that the thought of being a cuckold causes him pain but that he is not willing to confront his wife directly with his suspicions. The end of Act 3, scene 3, is the climax of Othello. Convinced of his wife’s corruption, Othello makes a sacred oath never to change his mind about her or to soften his feelings toward her until he enacts an act of violent revenge. At this point, Othello is fixed in his course, and the disastrous ending of the play is unavoidable. Othello replaces the security of his marriage with the hateful paranoia of an alliance with Iago. Iago’s final words in this scene chillingly mock the language of love and marriage: “I am your own forever” (III.iii.482).