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At first glance, I didn’t really understand much and have no background in french so the title didn’t help me either. After a translation, I found it to mean “The Beautiful Lady Without Mercy”. The poem is a ballad. It revolves around a Knight who falls in love with a fairy-like woman and gets enchanted by her. He imagines everything the woman says as a declaration of love – “And sure in language strange she said— ‘I love thee true’” and everything she does as a lover’s touch. He pours his energy into making her “bracelets” and “garlands” in return for her affection and love. The poem takes place in the “meads” or a meadow, it starts here and goes full circle and ends here as well. His love for the fairy-like woman slowly transforms into obsession and he cherishes every illusion and thought he’s had of her. His obsession has made him a victim of the beautiful lady without mercy and is now lifeless and “Alone and palely loitering” near the lake desperate for an illusion of the fairy-like woman. I think the poem is very complicated and indirect, I couldn’t really figure it out until multiple readings and peer discussions. 

 

• division of a diploid (2 set of chromosomes) nucleus to form 2 genetically identical daughter cells 
• Happening in every tissue in body to replace cells 
• Requires exact duplication method

• Have cells which last for a lifespan (lens cells, brain) 
• To replace cells normally
  • May be due to damage
  • Become old and need to be replaced
  • Depends on the cell for how long it lasts
• Reproduce cells which are genetically identical 
  • Can carry out same function
• Cells on average replaced every 7-10 years 
  • Some replaced rapidly

• G1 S and G2 is interphase (90%)
• G1 grow, copy organelles
• S copy its DNA – 2 strands of DNA linked together by centromere 
• G2 similar to G1 – growth and checking DNA, check if copying is done correctly 

• Ribosomes – make more proteins
• Mitochondria – can copy and divide themselves into two
• RER – synthesise more proteins
• Need more of every cell organelles
• G1 copies cell organelles – need to make more enzymes (carries out reactions in cells)

• coiling of chromosomes which condenses chromosomes at the start of mitosis, allows DNA to be arranged
• Histones allow condensation of DNA into smaller space in eukaryotes
• Allows us to separate chromosomes in ordered manner during mitosis

• Every gene every allele same in double stranded chromosome 

• Count chromosomes by the centromeres 

• Replication of DNA
• Sister chromatids are 2 identical DNA molecules held together by centromere 
• Sister chromatids separated during mitosis to form 2 genetically identical nuclei 
• Identified because no visible chromosomes 

• Chromosomes coiled up
• More gaps in nucleus, nuclear envelope is breaking down 

1.6 Cyclins and Cancer

• Cyclins are proteins 
• Cyclin D rises during G1
  • Copies organelles
  • Will only rise to high position if everything going well
• Cyclin E rises during S phase (DNA replication)
• Cyclins act like a check point, continues and rises if everything in the cells is okay
  • If things are not okay, the cell exits the cell cycle and may kill itself (cell apoptosis) 
• Cyclin A – if dna damage is detected, things will bind to DNA damage which will lead to cell stopping there instead of exit

Cyclin 

• Proteins that control cell cycle
• Ensure tasks are carried out at the right time 
• Binds to CDk
  • Cyclin dependent kinase 
    • Depends on cyclin to be activated
  • If cyclin raises in conc and cyclin can bind to cyclin dependent kinase, kinase will be activated 
    • cyclin dependent kinase will add phosphate group – get active enzymes and cause next phase to continue

If we don’t have cyclin 

• Cyclin dependent kinase remains inactive, don’t get phosphorylation 
• If this was during s phase then dna replication switched off

Sea urchin 

• Lucky coincidence: serendipity 
• scientist discovered presence of cyclins 
• scientist researching sea urchins
• This was in fertilised cell of urchin
  • When it grows and develops you expect proteins to get higher in concentration 
  • And for the MIMIMI bands to get darker
  • As time went on there was an increase in darkness of bands, but some of the proteins were separated 
    • Some were there, not there, strongly there (cyclin in and out)
• Mitosis Interphase MI MI

How does cancer form?

• Normal cells
  • If they don’t have growth factors then no division 
  • Could be stem cells 
  • For some cases, with growth factors they will divide ·controlled)
• Cancer cells
  • Whether they have growth factors or no they still divide (continuous, nt responding to signals elsewhere, uncontrolled)
  • Tumour growth of these cells in uncontrolled manner
  • Don’t perform their usual function

• Normal cells 
  • If there is some damage (eg dna damage from mutagen) 
    • Proteins bind to damage and lead to signals which cause cells to enter cell death (apoptosis)
    • Won’t reproduce or grow through cell cycle if can’t be fixed
• Cancer cells if get damage
  • Gets dna damage and maybe its had mutations in some of the proteins which should bind to dna damage and send signal 
    • Can’t respond as it should 
    • Does not have signal to say its damaged
    • Can’t enter apoptosis
    • Continues dividing 

Normal p53

• p53 goes to where there is dna damage
  • Binds to dna where its damage
  • Causes halt at G1 checkpoint
  • Tries to activate repair
  • Apoptosis triggered if repair impossible
  • Cell don’t pass on damaged dna 

Mutated p53

• Mutations in the gene for p53
• Does not halt at G1 checkpoint, instead progresses 
• Mutate genes supposed to stop cancer

How cancer caused

• Mutations in oncogene 
  • Genes where if we have a mutation, it could lead to increase in the amount the gene is used
    • Growth factor involved in increase cell division 
  • oncogene = accelerator 
    • Causing something to increase through mutation 
    • Caused by smoking etc 
• Tumor suppressor -> brakes 

Hypothetical series of mutations leading to cancer

Tumors

• Abnormal groups of cells 
• Uncontrolled ell growth 
• Divide continuously 
• Malignant tumours detach and move to new locations
• Caused by mutations to DNA 
• Can be benign where they adhere to each other and do not invade other tissues

• Cause mutations by smoking -> mutagens or carcinogenic (cause mutations in DNA)
• Cancer and smoking 
  • Correlated
  • As smoking increases do does risk of developing cancer
  • Huge increase in death rate due to cancers of the mouth 
  • But death rate due to other cancers is not significantly different 
  • Chemicals in smoke are carcinogenic and cause mutations in cells

My mock presentation was based on the decision that children of ISIS members would not be allowed to return to the UK.

Knowledge Question: Can our values about one thing change our perception of others?

My presentation wasn’t entirely focused on the theory of knowledge parts much. In my final presentation, I’ll focus on the TOK explanations and comparisons more which was lacking previously. I spoke a lot about my real-life situation which was taking up too much time and dominating my presentation. I need to write a more detailed overview with clear conclusions and thought processes. I would work on these details more on my final presentation.

 

• Sing to me of the man, Muse, the man of twists and turns.

This is the opening line. I think it perfectly encompasses Odysseus’s character. Odysseus is “the man of twists and turns” because his journey is anything but straightforward. He’s also very capable of thinking his way out of dangerous situations by thinking in twists and turns or outside the box.

• Much have I suffered, labored long and hard by now in the waves and wars. Add this to the total—bring the trial on!

Odysseus says this line to Calypso when she tells him he’s going to suffer if he leaves her island. He just sees this another trial in a long war to go home.

• My fame has reached the skies. Sunny Ithaca is my home. Atop her stands our seamark, Mount Neriton’s leafy ridges shimmering in the wind.

Kleos is like fame. The highest goal for the men in this book is kleos or fame. Odysseus is and can simply state the fact that he has achieved kleos and his home and family id much more important to him than fame.

• What would you change in your own award, and why?

I would make my award more genre specific and have a panel of judges varying from record label producers, famous artists in that genre to song writers for the same genre as well. I feel it would be fairest if we had the same theme and genre which will make it easier to have set rules and criteria. I would also have no limitations in age or other participant qualifications so that everyone would have access to take part in an event to find the next best artist. I also think that most panels are male directed and would have an equal male and female voice present for judging. I would make it a live show and have audience voting as well as judges.

• What did you realise about others’ awards? Questions you might raise?

I think other’s awards were too generalised or unfair in some rules about certain topics and themes. I would raise the question about there being more forms of art and literature and it should be free to access by anyone. I think it should be free of charge to participate or send in your pieces of work because many artists and authors might not be financially able or have guardians who don’t want their ward to participate which would restrict some passionate people.

The Zen Zen Zo workshop was a very interesting class. It was very physical theatre making use of the whole body. We worked with synchronising with sound and time. We learned how to fluently transition from one action to the other while also slowing or speeding our movements. I loved the change of tempo and working with speed. The most fun for me was walking the space with different speeds while also coordinating my movements with the person across from me. It was a worth all the muscle pains I got the next day 🙂 The workshop made me more energetic but also felt like a kind of meditation because of the soothing Japanese music. I think I significantly improved in ensemble awareness, working with physicality and fusing mind, voice and body together in a performance.

ATL SKILLS-

Understanding repertoire

 

• The ability to bring a character to life based on understanding of the role and its function in the play from which it is taken.

 

 

• Understanding of the process of moving from page to stage and contribution to the working process in order to craft and shape the performance.

 

Devising

 

• The quality of the individual role that the candidate has devised within the ensemble piece, and the ideas that underpin it.

 

Acting skills

 

• The quality of the candidate’s vocal and physical technique and use of the performance space.

• The ability to pace the performance and vary levels of emotional intensity.
• The confidence and consistency of the performance. 

  IDENTIFY ONE STRENGTH AND ONE AREA OF IMPROVEMENT FROM THE ATLs ABOVE:

  STRENGTH:

  Express Ideas Verbally Collaboration During the process of devising metamorphosis, I contributed a lot when it came to ideas and I supported and encouraged both Sayma and Stuti but the biggest role I played was when i needed to mediate between them and get them to agree on decisions we need to make like using or not using a ladder instead of blocks and the cutting of lines to shorten the performance.

  IMPROVEMENT TAKING INTO CONSIDERATION NEXT YEAR’S NEEDS:

  Manage time and meet deadlines I think the skill I need to improve on for next year is “set and work towards goals”. I think the area i needed to improve in this performance was learning my lines earlier on instead of the last minute. I think making small goals and working towards them would help me manage my time efficiently and not procrastinate.